Materials | 1 MINUTE READ

COC Used in Unique Crystallization Microplate

Topas's cyclic olefin copolymer (COC) selected for the In-Situ-1, an unusual crystallization microplate by MiTeGen LLC, Ithaca, N.Y.


Facebook Share Icon LinkedIn Share Icon Twitter Share Icon Share by EMail icon Print Icon

A cyclic olefin copolymer (COC) was selected over other thermoplastics for the In-Situ-1, an unusual crystallization microplate by MiTeGen LLC, Ithaca, N.Y., a provider of innovative consumables for X-ray diffraction, crystallography, and protein crystallization of academic, pharmaceutical, industrial, and government research.

The Topas COC from Topas Advanced Polymers, Florence , Ky., was shown to outperform competitive thermoplastics like PET, PS, PE, and PI due to its superior moisture vapor resistance and X-ray transparency (92% clarity), along with excellent UV transparency and low birefringence. The COC’s versatility and advanced processability enables MiTeGen to combine an injection molded COC frame with a thin extruded COC film to generate a two-piece system with the performance benefits of both parts. The 5.04-in. by 3.35-in. rigid frame allows for physical features such as ledges and channels that provide consistent results from one experiment to the next. The 3.94-mil thickness thin film bottom which is ultrasonically welded to the rigid frame, provides a surface for crystal growth drops to be dispensed and easily analyzed over a broad spectrum from visible light to X-rays.

“With the help of cyclic olefin copolymers, we are pushing the boundaries when it comes to in-situ X-ray analysis, Our new crystallization plate design allows researchers to access another technique, so they can screen protein crystals in-situ compared to the previous plates which required manual crystal harvesting,” says MiTeGen’s business development director Benjamin Apker.

Want to find or compare materials data for different resins, grades, or suppliers? Check out Plastics Technology’s Plaspec Global materials database